With advances in engineered antibody designs, treatment performance improves, but higher aggregate levels are often produced in the cell culture creating new purification challenges. Current solutions for aggregate removal include bind and elute strategies with cation exchange or hydrophobic interaction chromatography resins. Though effective, these often result in poor process economics and low recoveries. Alternatively, caprylic acid has been successfully used as a flocculant for antibody aggregates but requires a filtration step resulting in a more labor intensive and complicated process. In this presentation, learn about a new, innovative approach to aggregate removal leveraging a flow through chromatography strategy.