This talk will focus on biopharmaceutical process development using microbial systems, such as bacteria and yeast. The discussion will cover key aspects such as optimization of expression for the target proteins, downstream process development, and high throughput approaches for rapid parameter screening. The talk will emphasize the innovative SMART Process Design platform, which assists in streamlining workflows and considering capacity limitations during process development. Automation, parallelization, and integrated process models will be highlighted for their role in enhancing efficiency, facilitating data-driven decision-making, and identifying optimization opportunities. Boehringer Ingelheim RCV's commitment to advanced technologies and data-driven strategies in delivering innovative bioprocess solutions for the digital transformation of the biopharmaceutical industry will be emphasized throughout the presentation.